Effects of Fenformin On Cell Viability and FGFR2 Expression in PC-3 Human Prostate Cancer Cell Line
نویسندگان
چکیده
Prostat kanseri, erkeklerde kansere bağlı ölümlerin ikinci en sık nedenidir. Kemoterapötiklere direnç gelişmesi nedeniyle prostat kanserini tedavi etmek için yeni ilaçlara ihtiyaç vardır. Fenformin biguanid grubu antidiyabetik bir ilaçtır ve antikanserojen etkileri de Fibroblast büyüme faktörü reseptörü 2 (FGFR2), hücre proliferasyonunu farklılaşmasını destekleyen membran reseptörüdür. Çalışmamızda; PC-3 insan kanseri hücrelerinde fenforminin FGFR2 üzerinden etkilerinin araştırılması amaçlandı. Deney grupları; kontrol grubu, 1 mM, 5 mM 10 fenformin uygulanan gruplar idi. uygulamalarından 24 saat sonra WST-1 canlılığı analizi yapıldı, ayrıca immunositokimyasal boyamadan H-Skoru hesaplandı. İstatistiksel analizler SPSS programı kullanıldı. sonuçlarına göre; ile karşılaştırıldığında canlılığında istatistiksel olarak anlamlı derecede azalma tespit edildi (p<0.05, hepsi için). arasındaki ekspresyonunun azalması anlamlıydı Çalışmamızda fenformin, doza hücreleri üzerinde ekspresyonunu azaltıcı inhibe edici etkiler göstermiştir. En etkili dozun olduğu edilmiştir.
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ژورنال
عنوان ژورنال: Mu?la S?tk? Koçman üniversitesi t?p dergisi
سال: 2023
ISSN: ['2148-8118', '2618-6020']
DOI: https://doi.org/10.47572/muskutd.1024832